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Famotidine
3-[2-(diaminomethyleneamino)thiazol- 4-ylmethylthio]-N-sulfamoylpropionamidine
CAS number 76824-35-6	ATC code A02BA03
Chemical formula	C8H15N7O2S3
Molecular weight	337.5
Bioavailability	40-45%
Metabolism	hepatic
Elimination half-life	2-3.5 hours
Excretion	renal
Pregnancy category	B1 (Australia)
Legal status	Schedule 4 (Aust) POM (UK)
Routes of administration	oral

Famotidine is a histamine H₂-receptor antagonist that inhibits stomach acid production, and is commonly used in the treatment of peptic ulcer disease (PUD) and gastroesophageal reflux disease (GERD).

Clinical use

Main article: H2-receptor antagonist

Certain preparations of famotidine are available over the counter (OTC) in various countries. In the United States, preparations of 10 mg and 20mg tablets, sometimes in combination with a more traditional antacid (brand name Pepcid Complete), are available OTC. Larger doses still require a prescription.

History and development

Famotidine was developed by Merck & Co.. The imidazole-ring of cimetidine was replaced with a 2-guanidinothiazole ring. Famotidine proved to be 30 times more active than cimetidine.

It was first marketed (as Pepcidine® and Pepcid®) in 1985. Pepcid RPD® (orally disintegrating tablets that are not swallowed) was released in 1999. Generic forms (e.g. Fluxid®, Schwarz Pharma) became available in 2001.

In the United States, a product called Pepcid Complete is available that combines famotidine with an antacid in a chewable tablet to ameliorate the relatively slow onset of effects.

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